Chris - "how do the tobacco and alcohol producers manage to keep their product just affordable, and ensure mounting profits year on year?"
That's easy - by expanding into less regulated and more profitable markets. According to a report on the recently announced British American Tobacco Company's increased profits for the year:
"The London-listed company is seeking to grow business further in emerging markets across Africa, Asia, Eastern Europe, Latin America and the Middle East, as Western governments seek to cut cigarette usage in their countries."
That's the 'benefit' of globalisation, Chris - it allows your company to continue making profits at the expense of causing cancer in your customers, out of sight and out of mind overseas, thus paying your shareholders a nice little dividend each year so they can afford their expensive holiday home on Sandbanks.